Dzhelepov Laboratory of Nuclear Problems

Scientific and Technical Seminar “Medical Physics and Radiobiology”

Date and Time: Thursday, 24 November 2022, at 11:00 AM

Venue: Conference Hall of Scientific and Administrative Division “Phasotron Department”, Dzhelepov Laboratory of Nuclear Problems

Seminar topic: “General patterns and locus specific features of radiomutability of sex-linked and autosomal genes of Drosophila melanogaster”

Authors: I. D. Alexandrov, M. V. Alexandrova, K. P. Afanasyeva, A. N. Rusakovich, N. E. Kharchenko

Speaker: I. D. Alexandrov

Abstract:

The results of a comprehensive genetic and cytogenetic analysis of the nature and frequency of inherited locus specific mutations induced by ⁶⁰Co γ-radiation and 0.85 MeV neutrons in mature sperms of Drosophila melanogaster males are presented and discussed. A common pattern for different genes and types of radiation in the induction of two main classes of mutations inherited by the progeny of irradiated parents has been established:

1. Gene mutations associated with chromosomal aberrations (multilocus deletions, inversions, translocations);

2. Gene “point” mutations caused by changes in DNA of various types. The induction of chromosomal aberrations of one type or another is individual for different genes and is determined by the location of the gene in the chromosome and the 3D sperm genome. Whereas the frequency of “point” mutations induction is invariant for the five genes studied and two types of radiation.